The therapeutic effects produced by MnPs are beneficial for both protecting normal tissue and inhibiting tumor tissues. MnPs suppress tumor growth, while enabling healing of normal cell/tissue injury and preventing such injury.

Data suggests that the oxidation of the NF-kB protein is the core of MnP activity. The MnP-dependent oxidation of Nrf2/Keap1 and scavenging of reactive oxygen species are also components of the mechanism of action of this new class of drug.

The above illustration shows that in normal tissues, oxidative stress has the effect of activating NFkB resulting in the release of pro inflammatory cytokines and at the same time activating the Nrf2 pathway, stimulating the production of anti-inflammatory enzymes which will control the inflammatory response. MnPs block the NFkB activation and further stimulate the Nrf2 pathway.