Reviews
Batinic-Haberle I et al. Mn Porphyrin-Based Redox-Active Drugs: Differential Effects as Cancer Therapeutics and Protectors of Normal Tissue Against Oxidative Injury. Antioxid Redox Signal. 2018 Aug 28.
Batinic-Haberle I et al. SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathways. Antioxid Redox Signal. 2014 May 20;20(15):2372-415.
Batinic-Haberle I et al. Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential. Antioxid Redox Signal. 2010 Sep 15;13(6):877-918.
Thiol regulation by Mn porphyrins, commonly known as SOD mimics. Batinic-Haberle I, Tome ME. Redox Biol. 2019 Feb 13:101139
PMID: 31126869
Utilizing Superoxide Dismutase Mimetics to Enhance Radiation Therapy Response While Protecting Normal Tissues. Mapuskar KA, Anderson CM, Spitz DR, Batinic-Haberle I, Allen BG, E Oberley-Deegan R. Semin Radiat Oncol. 2019 Jan; 29(1):72-80. Review.
PMID: 30573187
Safety
Gad SC et al. A nonclinical safety assessment of MnTE-2-PyP, a manganese porphyrin.
Int J Toxicol. 2013 Jul;32(4):274-87.
Gad SC et al. Nonclinical Safety and Toxicokinetics of MnTnBuOE-2-PyP5+ (BMX-001).
Int J Toxicol. 2016 Jul;35(4):438-53.
Oncology
Archambeau JO et al. Superoxide dismutase mimic, MnTE-2-PyP(5+) ameliorates acute and chronic proctitis following focal proton irradiation of the rat rectum.
Redox Biol. 2013 Oct 25;1:599-607.
Makinde et al. Effect of a Metalloporphyrin Antioxidant (MnTE-2-PyP) on the Response of a Mouse Prostate Cancer Model to Radiation.
Anticancer Res. 2009 Jan;29(1):107-18.
Sheng H et al. Long-term neuroprotection from a potent redox-modulating metalloporphyrin in the rat.
Free Radic Biol Med. 2009 Oct 1;47(7):917-23.
Birer SR et al. Inhibition of the Continuum of Radiation-Induced Normal Tissue Injury by a Redox-Active Mn Porphyrin.
Radiat Res. 2017 Jul;188(1):94-104.
Oberley-Deegan RE et al. The antioxidant, MnTE-2-PyP, prevents side-effects incurred by prostate cancer irradiation.
PLoS One. 2012;7(9):e44178.
Tovmasyan A et al. Radiation-Mediated Tumor Growth Inhibition Is Significantly Enhanced with Redox-Active Compounds That Cycle with Ascorbate.
Antioxid Redox Signal. 2018 Nov 1;29(13):1196-1214.
Gauter-Fleckenstein B et. al. Early and late administration of MnTE-2-PyP5+ in mitigation and treatment of radiation-induced lung damage.
Free Radic Biol Med. 2010 Apr 15;48(8):1034-43.
Pearlstein RD et al. Metalloporphyrin antioxidants ameliorate normal tissue radiation damage in rat brain.
Int J Radiat Biol. 2010 Feb;86(2):145-63.
Vujaskovic Z. et al. A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injury.
Free Radic Biol Med. 2002 Sep 15;33(6):857-63.