Chemistry and Mechanism of Action

Mechanism of Action

Modulates Nuclear Transcription

  • NF-κB Inhibition
  • Nrf-2 Activation

Proven In Vitro Activities of BMX-001 and BMX-010

  • Attenuate O2Mediated Injury
  • Attenuate H2O2 Mediated Injury
  • Prevent Formation of Lipid Peroxides
  • Scavenge ONOO
  • Glutathionylation
  • Modulate Nuclear Transcription
  • NfKB Inhibition
  • Modulate T-Cell Function
  • TGFβ Inhibition

Oncology

Activity in Cancer

  • High Grade Glioma
  • Head and Neck Cancer
  • Prostate Cancer
  • Colon Cancer
  • Breast Cancer
  • Multiple Brain Metastases
  • Radiation Induced Tissue Injury (evidence from animal models in the lung, bowel, skin, oral/pharyngeal, and brain)
  • Chemotherapy Induced

Dermatology

Activity in Disease Models

  • Inflammatory Skin Diseases
  • Pruritus