Chemistry and Mechanism of Action

Mechanism of Action

Modulates Nuclear Transcription

  • NF-κB Inhibition
  • Nrf-2 Activation

Preferential Accumulation in Tumor Cells Doubling the Rate of Tumor Cell Killing

Proven In Vitro Activities of BMX-001 and BMX-010

  • Attenuate O2Mediated Injury
  • Attenuate H2O2 Mediated Injury
  • Prevent Formation of Lipid Peroxides
  • Scavenge ONOO
  • Glutathionylation
  • Modulate Nuclear Transcription
  • NfKB Inhibition
  • Modulate T-Cell Function
  • TGFβ Inhibition

Oncology

Activity in Cancer

Demonstrable Efficacy Across a Range of Cancers

BMX-001 can be used across a range of cancer types to improve therapeutic benefits to patients, including:

  • High Grade Glioma*
  • Multiple brain metastases derived from lung, breast and renal primaries*
  • Head and Neck Cancer*
  • Melanoma, Ovarian Cancer, Breast Cancer, Colorectal Cancer, Prostate Cancer

* Clinical Trials are in process. Other cancers are supported by pre-clinical animal data demonstrating efficacy.

Dermatology

Activity in Disease Models

  • Inflammatory Skin Diseases
  • Pruritus