Mechanism of Action
Modulates Nuclear Transcription
NF-κB Inhibition
Nrf-2 Activation
Preferential Accumulation in Tumor Cells Doubling the Rate of Tumor Cell Killing
Proven In Vitro Activities of BMX-001 and BMX-010
Attenuate O2– Mediated Injury
Attenuate H2O2 Mediated Injury
Prevent Formation of Lipid Peroxides
Scavenge ONOO–
Glutathionylation
Modulate Nuclear Transcription
NfKB Inhibition
Modulate T-Cell Function
TGFβ Inhibition
Oncology
Activity in Cancer
Demonstrable Efficacy Across a Range of Cancers
BMX-001 can be used across a range of cancer types to improve therapeutic benefits to patients, including:
- Multiple brain metastases derived from lung, breast and renal primaries*
- Head and Neck Cancer*
- Melanoma
- Ovarian Cancer
- Breast Cancer
- Colorectal Cancer
- Prostate Cancer
* Clinical Trials are in process. Other cancers are supported by pre-clinical animal data demonstrating efficacy.
Dermatology
Activity in Disease Models
- Inflammatory Skin Diseases
- Pruritus
