Chemistry and Mechanism of Action

Mechanism of Action

Modulates Nuclear Transcription


NF-κB Inhibition
Nrf-2 Activation

Preferential Accumulation in Tumor Cells Doubling the Rate of Tumor Cell Killing

Proven In Vitro Activities of BMX-001 and BMX-010

Attenuate O2– Mediated Injury
Attenuate H2O2 Mediated Injury
Prevent Formation of Lipid Peroxides
Scavenge ONOO–
Modulate Nuclear Transcription
NfKB Inhibition
Modulate T-Cell Function
TGFβ Inhibition


Activity in Cancer

Demonstrable Efficacy Across a Range of Cancers


BMX-001 can be used across a range of cancer types to improve therapeutic benefits to patients, including:

  • Multiple brain metastases derived from lung, breast and renal primaries*
  • Head and Neck Cancer*
  • Melanoma
  • Ovarian Cancer
  • Breast Cancer
  • Colorectal Cancer
  • Prostate Cancer

* Clinical Trials are in process. Other cancers are supported by pre-clinical animal data demonstrating efficacy.


Activity in Disease Models


  • Inflammatory Skin Diseases
  • Pruritus

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